Pre_GI Gene

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Host: NC_016768 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016768:2704350 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27043502705081732hypothetical proteinBLASTP
27050782706046969nucleotide-sugar epimerase epiAQuickGO ontologyBLASTP
270604327070651023GDP-D-mannose dehydratase gmdAQuickGO ontologyBLASTP
270754627088441299hypothetical proteinBLASTP
27090462709927882hypothetical proteinBLASTP
27099112710273363hypothetical proteinBLASTP
271024527120441800membrane proteinQuickGO ontologyBLASTP
27122802712783504hypothetical proteinBLASTP
27127172713412696hypothetical proteinBLASTP
27136962714196501hypothetical proteinBLASTP
27141932714858666hypothetical proteinBLASTP
27149952715594600hypothetical proteinBLASTP
27156012716143543hypothetical proteinBLASTP
27163162717215900hypothetical proteinBLASTP
27174282718249822hypothetical proteinBLASTP
271826127192891029glycosyltransferaseQuickGO ontologyBLASTP
27193342719732399hypothetical proteinBLASTP
27197932720005213hypothetical proteinBLASTP
27202192720836618methyltransferaseQuickGO ontologyBLASTP
272090927221951287esterase lipLQuickGO ontologyBLASTP
272225127232521002arginineornithine transport system ATPaseQuickGO ontologyBLASTP
27232522723569318hypothetical proteinBLASTP
27235662723868303hypothetical proteinBLASTP
272388227261342253methylmalonyl-CoA mutase large subunit mutBQuickGO ontologyBLASTP
272613527279821848methylmalonyl-CoA mutase small subunit mutAQuickGO ontologyBLASTP
27281732728931759hypothetical proteinBLASTP
272951027308171308membrane proteinQuickGO ontologyBLASTP