Pre_GI Gene

Some Help

Host: NC_016768 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016768:2521225 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
252122525225561332hypothetical proteinBLASTP
25225652522960396membrane proteinQuickGO ontologyBLASTP
25229652523312348hypothetical proteinBLASTP
25233452523707363hypothetical proteinBLASTP
252403325258081776macrolide-transport ATP-binding protein ABC transporterQuickGO ontologyBLASTP
252582325271151293cytochrome P450 139 cyp139QuickGO ontologyBLASTP
252709825281591062chalcone synthase pks11QuickGO ontologyBLASTP
252830625313593054polyketide synthase pks9QuickGO ontologyBLASTP
253136525328971533polyketide synthaseQuickGO ontologyBLASTP
253287325376814809polyketide synthaseQuickGO ontologyBLASTP
253770125440816381polyketide synthase pks7QuickGO ontologyBLASTP
254416425452251062chalcone synthase pks10QuickGO ontologyBLASTP