Pre_GI Gene

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Host: NC_016768 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016768:1769332 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17693321770129798hypothetical proteinBLASTP
17701221771012891long-chain C50-Z-isoprenyl diphosphate synthaseQuickGO ontologyBLASTP
17710121771440429hypothetical proteinBLASTP
17715481771940393ferric uptake regulation protein furBQuickGO ontologyBLASTP
17719371772344408ArsR family transcriptional regulatorQuickGO ontologyBLASTP
177252617739171392glycyl-tRNA synthetase glySQuickGO ontologyBLASTP
177405517759021848PPE family proteinQuickGO ontologyBLASTP
177664017785081869PPE family proteinQuickGO ontologyBLASTP
177893817801131176PPE family proteinQuickGO ontologyBLASTP
17802021780501300esat-6 like protein EsxJQuickGO ontologyBLASTP
17805161780800285esat-6 like protein EsxIQuickGO ontologyBLASTP
17810551781381327transposaseQuickGO ontologyBLASTP
17814321782316885transposaseQuickGO ontologyBLASTP
178238017835551176PPE family proteinQuickGO ontologyBLASTP
178437917859411563membrane-associated phospholipase C 1 plcAQuickGO ontologyBLASTP
178613217876971566membrane-associated phospholipase C 2 plcBQuickGO ontologyBLASTP
178775617893061551phospholipase C 3 plcCQuickGO ontologyBLASTP
17894981789824327hypothetical proteinBLASTP
17899591790255297esat-6 like protein EsxPQuickGO ontologyBLASTP
17903061790590285esat-6 like protein EsxOQuickGO ontologyBLASTP
179067517926571983hypothetical proteinBLASTP