Pre_GI Gene

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Host: NC_016582 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016582:2069677 Streptomyces bingchenggensis BCW-1 chromosome, complete genome

Host Lineage: Streptomyces bingchenggensis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Streptomyces bingchenggensis BCW-1 was isolated from a soil sample collected in Harbin, China. This species produces milbemycins, a family of macrocyclic lactones widely used in human health, animal health, and crop protection. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20687962069680885glyoxalasebleomycin resistance proteindioxygenaseQuickGO ontologyBLASTP
20696772070870119424-dienoyl-CoA reductase NADPHQuickGO ontologyBLASTP
207088820718089212-hydroxyhepta-24-diene-17-dioate isomeraseQuickGO ontologyBLASTP
207209920728937952-oxopent-4-enoate hydrataseQuickGO ontologyBLASTP
20728902073795906acetaldehyde dehydrogenaseQuickGO ontologyBLASTP
2073792207488010894-hydroxy-2-ketovalerate aldolaseQuickGO ontologyBLASTP
207487720756567804-oxalocrotonate decarboxylaseQuickGO ontologyBLASTP
207565820758792224-oxalocrotonate tautomeraseQuickGO ontologyBLASTP
207587920773271449Betaine-aldehyde dehydrogenaseQuickGO ontologyBLASTP
20773732077759387hypothetical proteinBLASTP
207788120828304950putative type I polyketide synthaseQuickGO ontologyBLASTP
208289920905787680putative type I polyketide synthaseQuickGO ontologyBLASTP
209205820940582001Mycocerosate synthase Erythronolide synthaseQuickGO ontologyBLASTP
209411220951491038hypothetical proteinBLASTP
209518521021326948putative type I polyketide synthaseQuickGO ontologyBLASTP