Pre_GI Gene

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Host: NC_015571 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015571:801715 Porphyromonas gingivalis TDC60, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
801715802557843undecaprenol kinaseQuickGO ontologyBLASTP
802665802892228hypothetical proteinBLASTP
802939803766828cell division protein FtsXQuickGO ontologyBLASTP
804172804303132hypothetical protein
805749806090342transcriptional regulatorQuickGO ontologyBLASTP
806093806482390hypothetical proteinBLASTP
8064798085272049TOPRIM domain-containing proteinQuickGO ontologyBLASTP
808524808718195hypothetical proteinBLASTP
808865808999135hypothetical protein
809573809695123transposase and inactivated derivatives in ISPg10QuickGO ontologyBLASTP
810001810114114hypothetical protein
810137811027891hypothetical proteinBLASTP
8110248131622139hypothetical proteinBLASTP
8132898146141326hypothetical proteinBLASTP
814658814879222hypothetical proteinBLASTP
8150688165191452hypothetical proteinBLASTP
8165878177051119isochorismate synthaseQuickGO ontologyBLASTP
81770281943817372-succinyl-6-hydroxy-2 4-cyclohexadiene-1-carboxylic acid synthase2-oxoglutarate decarboxylaseQuickGO ontologyBLASTP
819457820281825naphthoate synthaseQuickGO ontologyBLASTP
8202818213511071mandelate racemasemuconate lactonizing enzyme family proteinQuickGO ontologyBLASTP
8213758224571083O-succinylbenzoic acid--CoA ligaseQuickGO ontologyBLASTP
822808822915108hypothetical proteinBLASTP
822935823603669HAD-superfamily hydrolase subfamily IA variant 1 family proteinQuickGO ontologyBLASTP
823686824234549hypothetical proteinBLASTP
8242458266742430hypothetical proteinBLASTP