Pre_GI Gene

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Host: NC_015571 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015571:411156 Porphyromonas gingivalis TDC60, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4111564122471092transposase in ISPg1QuickGO ontologyBLASTP
4126934147652073DNA topoisomerase IIIQuickGO ontologyBLASTP
415350415613264hypothetical proteinBLASTP
415664415909246hypothetical protein
4161104172461137glycosyl transferase group 4 family proteinQuickGO ontologyBLASTP
4174944187021209UDP-N-acetyl-D-mannosaminuronic acid dehydrogenaseQuickGO ontologyBLASTP
418988419974987putative glycosyltransferaseQuickGO ontologyBLASTP
4199444211491206hypothetical protein
4211594222171059putative glycosyl transferase family 1QuickGO ontologyBLASTP
4223024236361335putative coenzyme F390 synthetaseQuickGO ontologyBLASTP
423931424410480putative DNA-binding protein histone-like familyQuickGO ontologyBLASTP
424538424975438putative serine acetyltransferaseQuickGO ontologyBLASTP
4249694261531185putative delta-aminolevulinic acid dehydrataseQuickGO ontologyBLASTP
4261744272141041putative glycosyl transferase family 2QuickGO ontologyBLASTP
427256427954699WecBTagACpsF family glycosyl transferaseQuickGO ontologyBLASTP
4279604291201161UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP
429426429692267DNA-binding protein HUQuickGO ontologyBLASTP
429887430462576hypothetical protein
430522431142621hypothetical proteinBLASTP
431146431694549hypothetical protein
4316914328031113type I phosphodiesterasenucleotide pyrophosphatase family proteinQuickGO ontologyBLASTP