Pre_GI Gene

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Host: NC_015571 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015571:1207000 Porphyromonas gingivalis TDC60, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
120719312090731881hypothetical proteinBLASTP
12093131210266954glycerate dehydrogenaseQuickGO ontologyBLASTP
12104331210534102hypothetical protein
1210652121180011498-amino-7-oxononanoate synthaseQuickGO ontologyBLASTP
12118001212219420hypothetical proteinBLASTP
12122231212648426hypothetical proteinBLASTP
12128231212981159hypothetical proteinBLASTP
12130491213162114hypothetical proteinBLASTP
12133241213458135hypothetical protein
121347212157932322hypothetical proteinBLASTP
12159811216874894cell filamentation protein ficQuickGO ontologyBLASTP
12168861217092207transcriptional regulatorQuickGO ontologyBLASTP
12175561218107552histone-like family DNA-binding proteinQuickGO ontologyBLASTP
12181931218414222hypothetical proteinBLASTP
12184071218523117hypothetical proteinBLASTP
121862712205491923molecular chaperone DnaKQuickGO ontologyBLASTP
12207211220912192hypothetical protein
122111612226631548hypothetical proteinBLASTP
122271212244991788peptidase M24 familyQuickGO ontologyBLASTP
12245081225047540hexapeptide transferase family proteinQuickGO ontologyBLASTP
12251291226073945TPR domain-containing proteinQuickGO ontologyBLASTP
12261011226751651ribonuclease HQuickGO ontologyBLASTP
122670012279381239hypothetical proteinBLASTP
12282981229110813lipoproteinQuickGO ontologyBLASTP
12291071229262156hypothetical proteinBLASTP
12292521229584333hypothetical proteinBLASTP