Pre_GI Gene

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Host: NC_015571 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015571:1030527 Porphyromonas gingivalis TDC60, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
103052710360195493DNA methylaseQuickGO ontologyBLASTP
10360061036437432hypothetical proteinBLASTP
103671210388412130DNA topoisomerase IIIQuickGO ontologyBLASTP
103887610402701395hypothetical proteinBLASTP
10404931041101609transcriptional regulator TetR familyQuickGO ontologyBLASTP
1041114104227111583-oxoacyl-acyl-carrier-protein synthase IIIQuickGO ontologyBLASTP
104277810440761299radical SAM domain proteinQuickGO ontologyBLASTP
104407310463582286hypothetical proteinBLASTP
104651510486982184ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
10487001049194495hypothetical proteinBLASTP
10492441049498255hypothetical proteinBLASTP
10494851049844360RteC proteinQuickGO ontologyBLASTP
10499011050104204hypothetical protein
10501551050310156hypothetical protein
105041010524222013TraG family proteinQuickGO ontologyBLASTP
105243810536671230mobilization proteinQuickGO ontologyBLASTP
10536521054065414hypothetical proteinBLASTP
10540741054367294hypothetical proteinBLASTP
10548601055642783putative conjugate transposon protein TraAQuickGO ontologyBLASTP
10556261056054429hypothetical proteinBLASTP
10560801056433354hypothetical proteinBLASTP
10564301057023594hypothetical proteinBLASTP
10570531057793741conjugative transposon protein TraAQuickGO ontologyBLASTP
10577811058368588hypothetical proteinBLASTP
10585441058843300conjugative transposon protein TraEQuickGO ontologyBLASTP
10588481059225378conjugative transposon protein TraFQuickGO ontologyBLASTP
105922210617082487conjugative transposon protein TraGQuickGO ontologyBLASTP