Pre_GI Gene

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Host: NC_015425 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015425:841754 Clostridium botulinum BKT015925 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
841754842470717hypothetical proteinBLASTP
8431948445281335magnesium transporterQuickGO ontologyBLASTP
8449918467091719putative methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
846729847376648hypothetical proteinBLASTP
8475228483528314-deoxy-L-threo-5-hexosulose-uronate ketol-isomeraseQuickGO ontologyBLASTP
8484518492067562-deoxy-D-gluconate 3-dehydrogenaseQuickGO ontologyBLASTP
8492238498676452-dehydro-3-deoxyphosphogluconate aldolaseQuickGO ontologyBLASTP
84987785089610202-dehydro-3-deoxygluconokinaseQuickGO ontologyBLASTP
8509628521551194putative glucuronyl hydrolaseQuickGO ontologyBLASTP
8524048534381035ISCb1g3 transposaseQuickGO ontologyBLASTP
8535638547741212putative glucuronyl hydrolaseQuickGO ontologyBLASTP
854861855679819PTS system mannosefructosesorbose family transporter subunit IICQuickGO ontologyBLASTP
855681856496816PTS system mannosefructosesorbose family transporter subunit IICQuickGO ontologyBLASTP
856536856823288putative preprotein translocaseQuickGO ontology
8569708579891020lacI family transcriptional regulatorQuickGO ontologyBLASTP
8583768600671692arginyl-tRNA synthetaseQuickGO ontologyBLASTP
8602118629792769sigma-54 factor interaction domain-containing proteinQuickGO ontologyBLASTP
863224863643420PTS system mannosefructosesorbose family transporter subunit IIAQuickGO ontologyBLASTP
863643864116474PTS system mannosefructosesorbose family transporter subunit IIBQuickGO ontologyBLASTP