Pre_GI Gene

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Host: NC_015425 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015425:604842 Clostridium botulinum BKT015925 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6048426062181377RNA polymerase sigma-54 factorQuickGO ontologyBLASTP
6064226074831062transcriptional regulatorQuickGO ontologyBLASTP
6075426085461005type I glyceraldehyde-3-phosphate dehydrogenaseQuickGO ontologyBLASTP
608758608889132hypothetical protein
6091876103261140lipoproteinQuickGO ontologyBLASTP
6104336119981566sugar ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
6120066130821077sugar ABC transporter permeaseQuickGO ontologyBLASTP
613075613992918sugar ABC transporter permeaseQuickGO ontologyBLASTP
6143336155471215phosphoglycerate kinaseQuickGO ontologyBLASTP
615649616401753Triose-phosphate isomeraseQuickGO ontologyBLASTP
6164816180251545phosphoglycerate mutaseQuickGO ontologyBLASTP
6181406194411302phosphopyruvate hydrataseQuickGO ontologyBLASTP
619615619851237preprotein translocase subunit SecGQuickGO ontologyBLASTP
6200836221012019V-type H-translocating pyrophosphataseQuickGO ontologyBLASTP
6223606246002241ribonuclease RQuickGO ontologyBLASTP
624731625201471SsrA-binding proteinQuickGO ontologyBLASTP
626645627256612integrase catalytic subunitQuickGO ontologyBLASTP
627468627905438hypothetical protein
627889628299411hypothetical protein
629051630022972dihydrouridine synthase DuSQuickGO ontologyBLASTP
630261631256996hypothetical proteinBLASTP
631500632189690winged helix family two component transcriptional regulatorQuickGO ontologyBLASTP