Pre_GI Gene

Some Help

Host: NC_015425 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015425:369225 Clostridium botulinum BKT015925 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3692253726653441ATP-dependent deoxyribonuclease subunit BQuickGO ontologyBLASTP
3726203763543735ATP-dependent nuclease subunit AQuickGO ontologyBLASTP
376392377366975HD domain-containing proteinQuickGO ontologyBLASTP
3774633836036141putative cell wall associated proteinQuickGO ontologyBLASTP
383611383955345hypothetical proteinBLASTP
383997384221225hypothetical proteinBLASTP
384449385354906putative wall-associated proteinQuickGO ontologyBLASTP
385363386031669hypothetical protein
386186386305120hypothetical protein
3863773880591683putative wall-associated proteinQuickGO ontologyBLASTP
388086388313228hypothetical proteinBLASTP
388521389414894hypothetical proteinBLASTP
389476389694219RHS repeat familyQuickGO ontologyBLASTP
389818390357540hypothetical protein
390440390640201hypothetical protein
390878391534657hypothetical protein