Pre_GI Gene

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Host: NC_015425 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015425:2072703 Clostridium botulinum BKT015925 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
207159220727101119spore germination proteinQuickGO ontologyBLASTP
207270320741931491GerA spore germination proteinQuickGO ontologyBLASTP
207432420756011278uracil-xanthine permeaseQuickGO ontologyBLASTP
20758932076228336Early transcription factor 70 kDa subunitQuickGO ontology
20763992076986588MnFe superoxide dismutaseQuickGO ontologyBLASTP
207716020787521593Voltage gated chloride channel family proteinQuickGO ontologyBLASTP
207892920805271599sodiumsolute symporter family proteinQuickGO ontologyBLASTP
208106120820861026GfoIdhMocA family oxidoreductaseQuickGO ontologyBLASTP
20822212083117897xylose isomerase domain-containing protein TIM barrelQuickGO ontologyBLASTP
208323220842451014oxidoreductase domain-containing proteinQuickGO ontologyBLASTP
208434320862801938thiamine pyrophosphate protein central regionQuickGO ontologyBLASTP
20863032087091789myo-inositol catabolism IolB domain-containing proteinQuickGO ontologyBLASTP
208714420881601017PfkB domain-containing proteinQuickGO ontologyBLASTP
20881832089046864ketose-bisphosphate aldolaseQuickGO ontologyBLASTP
208907120902251155iron-containing alcohol dehydrogenaseQuickGO ontologyBLASTP
20905642091328765DeoR family transcriptional regulatorQuickGO ontologyBLASTP
20915932092561969hypothetical proteinBLASTP
209264420938251182hypothetical proteinBLASTP
20939052095959205523-cyclic-nucleotide 2-phosphodiesteraseQuickGO ontologyBLASTP
209608420971181035ISCb1g3 transposaseQuickGO ontologyBLASTP
20975982098053456hypothetical proteinBLASTP
209814121000301890transcriptional regulatorQuickGO ontologyBLASTP