Pre_GI Gene

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Host: NC_015425 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015425:1207314 Clostridium botulinum BKT015925 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
120731412093292016CheA signal transduction histidine kinaseQuickGO ontologyBLASTP
12093571209944588CheC inhibitor of MCP methylationQuickGO ontologyBLASTP
12099611210320360response regulator receiver proteinQuickGO ontologyBLASTP
12103601210761402putative chemotaxis protein CheWQuickGO ontologyBLASTP
12107821211777996flagellar motor switch protein FliMQuickGO ontologyBLASTP
121175812130111254flagellar motor switch protein FliNQuickGO ontologyBLASTP
12132171213492276flagellin synthesis regulator FlgMQuickGO ontologyBLASTP
12135241213961438hypothetical proteinBLASTP
121398212159251944flagellar hook-associated protein 1QuickGO ontologyBLASTP
121594712173711425putative flagellar hook-associated protein 3QuickGO ontologyBLASTP
12174331217864432flagellar assembly factor FliWQuickGO ontologyBLASTP
12178641218085222carbon storage regulator CsrAQuickGO ontologyBLASTP
12181141218452339flagellin family proteinQuickGO ontologyBLASTP
12184721218768297hypothetical protein
12187811219182402flagellar protein FliSQuickGO ontologyBLASTP
12192641219710447flagellar cap protein fliDQuickGO ontologyBLASTP
121974912207741026flagellar cap protein fliDQuickGO ontologyBLASTP
12207781221116339hypothetical protein
12212921222065774flagellin domain-containing proteinQuickGO ontologyBLASTP
122232812240701743hypothetical proteinBLASTP
12240851224432348hypothetical proteinBLASTP
122446812255291062nucleotidyl transferaseQuickGO ontologyBLASTP
122556012267141155UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP
12267281227411684putative methyltransferaseQuickGO ontologyBLASTP
122743312284611029N-acetylneuraminate synthaseQuickGO ontologyBLASTP
12285501228858309hypothetical proteinBLASTP
12289061229121216hypothetical proteinBLASTP
12291631229303141hypothetical protein
12293841229509126hypothetical protein
122954812306361089hypothetical proteinBLASTP