Pre_GI Gene

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Host: NC_014560 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014560:518582 Helicobacter pylori SJM180 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
518582519181600CAG pathogenicity island protein 13QuickGO ontologyBLASTP
519383520225843CAG pathogenicity island protein 12QuickGO ontologyBLASTP
520261520917657cag island proteinQuickGO ontologyBLASTP
521298522056759cag pathogenicity island protein VQuickGO ontologyBLASTP
5220615236681608cag pathogenicity island protein WQuickGO ontologyBLASTP
5237215252861566cag pathogenicity island protein XQuickGO ontologyBLASTP
5253015307815481cag island proteinQuickGO ontologyBLASTP
530916531515600cag pathogenicity island protein cag6QuickGO ontologyBLASTP
531520532512993cag island protein DNA transfer proteinQuickGO ontologyBLASTP
5325215347672247cag island protein DNA transfer proteinQuickGO ontologyBLASTP
534886535395510cag pathogenicity island protein GammaQuickGO ontologyBLASTP
5354055368501446cag pathogenicity island protein 3QuickGO ontologyBLASTP
536850537200351cag pathogenicity island protein EpsilonQuickGO ontologyBLASTP
537308537655348cag pathogenicity island protein cag1QuickGO ontologyBLASTP
537827538681855hypothetical proteinBLASTP
5389125403571446glutamine synthetaseQuickGO ontologyBLASTP
540581540883303hypothetical protein
54127554172445050S ribosomal protein L9QuickGO ontologyBLASTP
541728542270543ATP-dependent protease peptidase subunitQuickGO ontologyBLASTP
5422705436011332ATP-dependent protease ATP-binding subunit HslUQuickGO ontologyBLASTP
543601544506906GTP-binding protein EraQuickGO ontologyBLASTP
544503545495993conserved hypothetical secreted proteinQuickGO ontologyBLASTP