Pre_GI Gene

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Host: NC_014560 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014560:171931 Helicobacter pylori SJM180 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
171482171940459hypothetical protein
171931172194264hypothetical protein
1722271735071281collagenaseQuickGO ontologyBLASTP
173533174264732hypothetical proteinBLASTP
1743391754301092peptide chain release factor 2QuickGO ontologyBLASTP
1754911766661176molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
176676177443768flagellar biosynthesis protein FliRQuickGO ontologyBLASTP
177437178165729hypothetical proteinBLASTP
178271178489219hypothetical protein
178636179535900putative peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
179552180475924fructose-bisphosphate aldolaseQuickGO ontologyBLASTP
180497181060564elongation factor PQuickGO ontologyBLASTP
1815611828051245DNA-cytosine methyltransferaseQuickGO ontologyBLASTP
182792183562771hypothetical proteinBLASTP
1835371848831347putative restriction enzymeQuickGO ontologyBLASTP
1848761860901215hypothetical proteinBLASTP
1861601871881029sialic acid synthaseQuickGO ontologyBLASTP
187192187833642ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
1878331891071275apolipoprotein N-acyltransferaseQuickGO ontologyBLASTP
189332190033702hypothetical proteinBLASTP
1900431915481506lysyl-tRNA synthetaseQuickGO ontologyBLASTP
1915481927981251serine hydroxymethyltransferaseQuickGO ontologyBLASTP
192809193351543hypothetical protein
193373194182810hypothetical protein