Pre_GI Gene

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Host: NC_014560 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014560:1309470 Helicobacter pylori SJM180 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13088201309482663nicotinamide mononucleotide transporterQuickGO ontologyBLASTP
13094701310084615thiamine pyrophosphokinaseQuickGO ontologyBLASTP
13106181310749132hypothetical proteinBLASTP
1310746131109635150S ribosomal protein L17QuickGO ontologyBLASTP
131109613121301035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
1312142131276862730S ribosomal protein S4QuickGO ontologyBLASTP
1312778131317339630S ribosomal protein S11QuickGO ontologyBLASTP
1313196131355836330S ribosomal protein S13QuickGO ontologyBLASTP
13135621313675114hypothetical protein
13137531313971219translation initiation factor IF-1QuickGO ontologyBLASTP
13139711314732762methionine aminopeptidaseQuickGO ontologyBLASTP
131473213159941263preprotein translocase subunit SecYQuickGO ontologyBLASTP
1316037131643840250S ribosomal protein L15QuickGO ontologyBLASTP
1316456131689944430S ribosomal protein S5QuickGO ontologyBLASTP
1316914131727035750S ribosomal protein L18QuickGO ontologyBLASTP
1317284131782053750S ribosomal protein L6QuickGO ontologyBLASTP
1317831131822639630S ribosomal protein S8QuickGO ontologyBLASTP
1318236131842118630S ribosomal protein S14QuickGO ontologyBLASTP
1318431131897654650S ribosomal protein L5QuickGO ontologyBLASTP
1318989131921022250S ribosomal protein L24QuickGO ontologyBLASTP
1319210131957836950S ribosomal protein L14QuickGO ontologyBLASTP
1319581131984126130S ribosomal protein S17QuickGO ontologyBLASTP
1319855132005520150S ribosomal protein L29QuickGO ontologyBLASTP
1320042132046742650S ribosomal protein L16QuickGO ontologyBLASTP
1320470132117470530S ribosomal protein S3QuickGO ontologyBLASTP
1321178132154636950S ribosomal protein L22QuickGO ontologyBLASTP
1321556132183728230S ribosomal protein S19QuickGO ontologyBLASTP
1321848132267883150S ribosomal protein L2QuickGO ontologyBLASTP
1322695132297628250S ribosomal protein L23QuickGO ontologyBLASTP
1322980132362764850S ribosomal protein L4QuickGO ontologyBLASTP
1323662132423757650S ribosomal protein L3QuickGO ontologyBLASTP
1324274132458831530S ribosomal protein S10QuickGO ontologyBLASTP
132479613258811086hypothetical proteinBLASTP
13261131326697585hypothetical proteinBLASTP
13266711327285615ribonuclease HIIQuickGO ontologyBLASTP
13273291327508180hypothetical proteinBLASTP
132758713289781392fumarate hydrataseQuickGO ontologyBLASTP
13291571329534378hypothetical proteinBLASTP
132953913307771239hypothetical proteinBLASTP
13307741331772999putative cobalt-zinc-cadmium resistance protein CzcB putative signal peptideQuickGO ontologyBLASTP
133177313348803108putative heavy metal efflux pump CzcAQuickGO ontologyBLASTP
13348611335217357hypothetical proteinBLASTP
13352111335897687hypothetical proteinBLASTP