Pre_GI Gene

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Host: NC_014555 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014555:502151 Helicobacter pylori PeCan4 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from a Peruvian gastric cancer patient. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5021515035961446cag pathogenicity island protein cag3QuickGO ontologyBLASTP
503606504115510cag pathogenicity island protein cag4QuickGO ontologyBLASTP
5042555065012247cag pathogenicity island protein BetaQuickGO ontologyBLASTP
506510507502993virB11-like cag pathogenicity islandencoded protein ATPase proteinQuickGO ontologyBLASTP
507507508106600cag pathogenicity island protein ZQuickGO ontologyBLASTP
51065951075496hypothetical protein
5137925153571566cag pathogenicity island protein XQuickGO ontologyBLASTP
5154105170171608cag pathogenicity island protein WQuickGO ontologyBLASTP
517022517780759cag island proteinQuickGO ontologyBLASTP
518055518702648cag pathogenicity island protein cagU cag11QuickGO ontologyBLASTP
518718519560843CAG pathogenicity island protein 12QuickGO ontologyBLASTP
519762520361600CAG pathogenicity island protein 13QuickGO ontologyBLASTP
520795521007213hypothetical proteinBLASTP
521273521578306cag pathogenicity island protein cagQ cag14QuickGO ontologyBLASTP
521635521838204hypothetical proteinBLASTP
521835521996162hypothetical proteinBLASTP
5233055244351131cag pathogenicity island protein cagM cag16QuickGO ontologyBLASTP