Pre_GI Gene

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Host: NC_014555 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014555:47372 Helicobacter pylori PeCan4 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from a Peruvian gastric cancer patient. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4737248217846cytosine specific DNA methyltransferaseQuickGO ontologyBLASTP
48292497911500proline permease putPQuickGO ontologyBLASTP
49818533753558Prolinepyrroline-5-carboxylate dehydrogenaseQuickGO ontologyBLASTP
5370353906204hypothetical proteinBLASTP
5464055215576hypothetical proteinBLASTP
5521655956741hypothetical proteinBLASTP
5844359012570hypothetical proteinBLASTP
5902859288261hypothetical proteinBLASTP
59299607651467hypothetical proteinBLASTP
6117561522348hypothetical proteinBLASTP
6405864855798urease accessory proteinQuickGO ontologyBLASTP
6485565454600Urease accessory protein UreGQuickGO ontologyBLASTP
6548366229747urease accessory protein UreFQuickGO ontologyBLASTP
6625966771513urease accessory protein UreEQuickGO ontologyBLASTP
6677367360588urease accessory protein pH-dependent urea-transporterQuickGO ontologyBLASTP
6741667547132hypothetical protein
67569692781710urease subunit betaQuickGO ontologyBLASTP
6928269998717urease subunit alphaQuickGO ontologyBLASTP