Pre_GI Gene

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Host: NC_014555 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014555:1526775 Helicobacter pylori PeCan4 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from a Peruvian gastric cancer patient. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15267751527647873fructose-16-bisphosphataseQuickGO ontologyBLASTP
15276471527850204hypothetical protein
15278631528759897putative type II methylase proteinQuickGO ontologyBLASTP
15287521529483732hypothetical proteinBLASTP
15294841529630147hypothetical protein
15296981530024327hypothetical protein
153412815351951068integraserecombinase xerDQuickGO ontologyBLASTP
15355791536286708hypothetical proteinBLASTP
15364091536792384hypothetical proteinBLASTP
15371411537920780hypothetical proteinBLASTP
15379401538233294hypothetical proteinBLASTP
153824015397661527hypothetical proteinBLASTP
15397901540065276hypothetical proteinBLASTP
15400661540332267hypothetical proteinBLASTP
154037915427482370VirB4-like proteinQuickGO ontologyBLASTP
154275115447842034DNA topoisomerase I topAQuickGO ontologyBLASTP
154490115460701170VirB8 type IV secretion proteinQuickGO ontologyBLASTP
154607015475871518VirB9 type IV secretion proteinQuickGO ontologyBLASTP
154758715488521266VirB10 type IV secretion proteinQuickGO ontologyBLASTP
15489221549215294hypothetical proteinBLASTP
15492081549471264hypothetical proteinBLASTP
15494681549767300hypothetical proteinBLASTP
15497671550708942VirB11 type IV secretion ATPaseQuickGO ontologyBLASTP
15507051551160456hypothetical proteinBLASTP
15511571551447291hypothetical proteinBLASTP
15514481552005558hypothetical proteinBLASTP
155200615537541749conjugal transfer protein traGQuickGO ontologyBLASTP
15542661554547282hypothetical proteinBLASTP
15545401554854315hypothetical proteinBLASTP
155514915570591911hypothetical proteinBLASTP
155708415582561173hypothetical proteinBLASTP
15583001558584285hypothetical proteinBLASTP
15586631559319657chromosome partitioning protein ParAQuickGO ontologyBLASTP
156816415692011038hypothetical proteinBLASTP
156920215705961395hypothetical proteinBLASTP
157283615742361401hypothetical proteinBLASTP
15742881574566279hypothetical proteinBLASTP
157456815758301263hypothetical proteinBLASTP