Pre_GI Gene

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Host: NC_014555 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014555:1477934 Helicobacter pylori PeCan4 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from a Peruvian gastric cancer patient. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
147793414790941161selenocysteine synthaseQuickGO ontologyBLASTP
147917614803631188transcription elongation factor NusAQuickGO ontologyBLASTP
148061014843593750putative type IIS restriction-modification proteinQuickGO ontologyBLASTP
148456614867492184hypothetical proteinBLASTP
148688314897952913type III restriction enzymeQuickGO ontologyBLASTP
14897981490379582type III DNA modification enzyme methyltransferaseQuickGO ontologyBLASTP
149037614917221347type III DNA modification enzyme methyltransferaseQuickGO ontologyBLASTP
149176414936351872ATP-dependent DNA helicase RecGQuickGO ontologyBLASTP
14937171494064348hypothetical proteinBLASTP
14940681494703636hypothetical proteinBLASTP
14947001495452753exodeoxyribonuclease IIIQuickGO ontologyBLASTP
1495552149562776tRNA-PheQuickGO ontologyBLASTP
149563014970721443hypothetical proteinBLASTP
149730114986681368chromosomal replication initiation proteinQuickGO ontologyBLASTP
14988201499356537purine nucleoside phosphorylaseQuickGO ontologyBLASTP
14994031499642240hypothetical proteinBLASTP
149964315014361794glucosamine--fructose-6-phosphate aminotransferaseQuickGO ontologyBLASTP