Pre_GI Gene

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Host: NC_014335 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014335:4327584 Bacillus cereus biovar anthracis str. CI chromosome, complete

Host Lineage: Bacillus cereus; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain probably caused lethal anthrax in chimpanzee Leo in the rainforest of the Tai National Park, Cote d'Ivoire. It belongs to a collection of genetically closely related bacteria, isolated in 2001 and 2002 from deceased wild chimpanzees living in this rain forest area. An autopsy showed symptoms typical of anthrax, but the bacterium isolated was motile, unlike B.anthracis. This organism is a soil-dwelling opportunistic pathogen that causes food poisoning in infected individuals. The rapid onset is characterized by nausea and vomiting while the late onset is characterized by diarrhea and abdominal pain. The emetic disease is caused by a small stable dodecadepsipeptide cerulide whereas the diarrheal disease is caused by a heat labile enterotoxin. Some strains produce a potent cytotoxin that forms a pore in the membrane of eukaryotic cells and causes necrotic enteritis (death of intestinal epithelial cells) while the unique tripartite membrane lytic toxin hemolysin BL contributes to the diarrheal disease and destructive infections of the eye.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
43275844328522939malate dehydrogenaseQuickGO ontologyBLASTP
432854243298341293isocitrate dehydrogenaseQuickGO ontologyBLASTP
432999543311101116citrate synthaseQuickGO ontologyBLASTP
43315314331992462putative membrane spanning proteinQuickGO ontologyBLASTP
433241343335311119putative transmembrane proteinQuickGO ontologyBLASTP
43341074334496390cytoplasmic membrane proteinQuickGO ontologyBLASTP
433469643364531758pyruvate kinaseQuickGO ontologyBLASTP
433650743374669606-phosphofructokinaseQuickGO ontologyBLASTP
43375954338569975acetyl-CoA carboxylase subunit alphaQuickGO ontologyBLASTP
43385574339426870acetyl-CoA carboxylase subunit betaQuickGO ontologyBLASTP
43396124340256645GntR family transcriptional regulatorQuickGO ontologyBLASTP
434027143415091239malate dehydrogenaseQuickGO ontologyBLASTP
434161343449393327DNA polymerase III subunit alphaQuickGO ontologyBLASTP
43450574345395339hypothetical proteinBLASTP
43453924345895504hypothetical proteinBLASTP
43459474346879933DHH family phosphoesteraseQuickGO ontologyBLASTP