Pre_GI Gene

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Host: NC_014256 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014256:448710 Helicobacter pylori B8 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
452011452127117hypothetical protein
452304453038735hypothetical proteinBLASTP
453103453396294hypothetical proteinBLASTP
4534034549291527hypothetical proteinBLASTP
455488455736249DNA transfer proteinQuickGO ontologyBLASTP
4557574579102154protein virB4QuickGO ontologyBLASTP
4579134599462034DNA topoisomerase IQuickGO ontologyBLASTP
460138460437300hypothetical proteinBLASTP
460499461230732Type IV secretion system protein virB8QuickGO ontologyBLASTP
461230462117888component of conjugal plasmid transfer systemQuickGO ontologyBLASTP
462243462746504hypothetical proteinBLASTP
462746463504759DNA transformation compentancyQuickGO ontologyBLASTP
463629464009381DNA transformation compentancyQuickGO ontologyBLASTP
464079464372294hypothetical proteinBLASTP
464365464628264hypothetical proteinBLASTP
464625464924300hypothetical proteinBLASTP
464924465865942type IV secretion system protein VirB11QuickGO ontologyBLASTP
465862466317456hypothetical proteinBLASTP
466314466604291hypothetical proteinBLASTP
466879466989111hypothetical protein
4670384689331896hypothetical proteinBLASTP
468905469015111hypothetical protein
4692224704061185hypothetical proteinBLASTP
470450470734285hypothetical proteinBLASTP
470816471472657putative chromosome partitioning proteinQuickGO ontologyBLASTP
4717384792947557hypothetical proteinBLASTP