Pre_GI Gene

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Host: NC_014039 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014039:708427 Propionibacterium acnes SK137 chromosome, complete genome

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7084277100131587NADP transhydrogenase AB-specific alpha subunitQuickGO ontologyBLASTP
7100177114381422NADP transhydrogenase subunit betaQuickGO ontologyBLASTP
711584711904321ferredoxin family proteinQuickGO ontologyBLASTP
7119017130041104succinyldiaminopimelate transaminaseQuickGO ontologyBLASTP
713005713868864hypothetical proteinBLASTP
7139457149079632345-tetrahydropyridine-26-dicarboxylate N-succinyltransferaseQuickGO ontologyBLASTP
715054715215162hypothetical protein
7152887164181131amidinotransferaseQuickGO ontologyBLASTP
7165427176031062hypothetical proteinBLASTP
7176137189141302putative ATP synthase F0 A subunitQuickGO ontologyBLASTP
718927719535609transcriptional regulator TetR familyQuickGO ontologyBLASTP
7196597207381080succinyl-diaminopimelate desuccinylaseQuickGO ontologyBLASTP
720783721088306DivIVA domain proteinQuickGO ontologyBLASTP
721129721296168hypothetical proteinBLASTP
7213607225441185glycogen synthaseQuickGO ontologyBLASTP
7226617239141254glucose-1-phosphate adenylyltransferaseQuickGO ontologyBLASTP
723997724650654O-methyltransferaseQuickGO ontologyBLASTP
724720725601882dihydrodipicolinate synthaseQuickGO ontologyBLASTP
725652726065414putative twin arginine-targeting protein translocase TatBQuickGO ontologyBLASTP
7262187277921575cellulase glycosyl hydrolase family 5QuickGO ontologyBLASTP