Pre_GI Gene

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Host: NC_014039 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014039:334892 Propionibacterium acnes SK137 chromosome, complete genome

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3348923359051014hypothetical proteinBLASTP
336016336570555inorganic diphosphataseQuickGO ontologyBLASTP
3366973380701374D-alanyl-D-alanine carboxypeptidaseD-alanyl-D-alanine-endopeptidaseQuickGO ontologyBLASTP
338052339005954tRNAIle-lysidine synthetaseQuickGO ontologyBLASTP
339033339587555hypoxanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
3397293418822154Cell division protein FtsHQuickGO ontologyBLASTP
341947342522576GTP cyclohydrolase IQuickGO ontologyBLASTP
342640342888249hypothetical proteinBLASTP
342900343019120hypothetical protein
3431303442361107OmpA family proteinQuickGO ontologyBLASTP
344236344874639hypothetical proteinBLASTP
345123345602480hypothetical proteinBLASTP
345725346084360hypothetical proteinBLASTP
346274347248975hypothetical proteinBLASTP
347418347834417hypothetical proteinBLASTP
347890348735846dihydropteroate synthaseQuickGO ontologyBLASTP
348796349158363dihydroneopterin aldolaseQuickGO ontologyBLASTP
3491553497125582-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinaseQuickGO ontologyBLASTP
349709350245537hypothetical proteinBLASTP
350340351005666putative cell division topological specificity factor MinEQuickGO ontologyBLASTP
3510823522421161respiratory-chain NADH dehydrogenase 49 Kd subunitQuickGO ontologyBLASTP
352411352728318hypothetical proteinBLASTP
3529903555242535negative regulator of genetic competence ClpCMecBQuickGO ontologyBLASTP
3555773565841008hypothetical proteinBLASTP
356581357567987hypothetical proteinBLASTP
357564358328765hypothetical proteinBLASTP