Pre_GI Gene

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Host: NC_014039 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014039:1813205 Propionibacterium acnes SK137 chromosome, complete genome

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18132051814044840biotin-acetyl-CoA-carboxylase ligaseQuickGO ontologyBLASTP
18141761814547372hypothetical proteinBLASTP
181464018162141575carboxyl transferase domain proteinQuickGO ontologyBLASTP
18162261816441216hypothetical proteinBLASTP
18164191817084666septum formation protein MafQuickGO ontologyBLASTP
18170681817388321hypothetical protein
18176941818113420hypothetical proteinBLASTP
18181791818313135hypothetical protein
18183101819044735oxidoreductase short chain dehydrogenasereductase family proteinQuickGO ontologyBLASTP
18191491819952804putative phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
18200721820932861hypothetical proteinBLASTP
18209111821381471dicarboxylate carrier MatC domain proteinQuickGO ontologyBLASTP
182210918234851377hypothetical proteinBLASTP
18236831824681999putative magnesium and cobalt transport protein CorAQuickGO ontologyBLASTP
18246781825190513hydrolase NUDIX familyQuickGO ontologyBLASTP
182544518272141770phosphoribosylglycinamide synthetase ATP-grasp A domain proteinQuickGO ontologyBLASTP
18272411827993753hypothetical proteinBLASTP
182803218294111380putative dihydrolipoamide dehydrogenase LpdAQuickGO ontologyBLASTP
18295491830412864putative purine nucleotide phosphorylaseQuickGO ontologyBLASTP
183043918321151677phosphoglucomutasephosphomannomutase alphabetaalpha domain IIQuickGO ontologyBLASTP
183214718338201674AMP-binding enzymeQuickGO ontologyBLASTP
18341381834656519hypothetical proteinBLASTP
183473718363891653transporter major facilitator family proteinQuickGO ontologyBLASTP