Pre_GI Gene

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Host: NC_014039 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014039:15236 Propionibacterium acnes SK137 chromosome, complete genome

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1523616204969lactatemalate dehydrogenase NAD binding domain proteinQuickGO ontologyBLASTP
16721178721152transcriptional regulator LacI familyQuickGO ontologyBLASTP
17869192301362putative ABC-type sugar transport system ATP-binding proteinQuickGO ontologyBLASTP
19289202901002ribose ABC transport system permease protein RbsCribose ABC transport system periplasmic ribose-binding protein RbsBQuickGO ontologyBLASTP
2033921280942ribose ABC transport system permease protein RbsCribose ABC transport system periplasmic ribose-binding protein RbsBQuickGO ontologyBLASTP
2127722206930putative ribokinaseQuickGO ontologyBLASTP
2220322586384Ribose ABC transport system high affinity permease RbsDQuickGO ontologyBLASTP
2290523039135hypothetical proteinBLASTP
2319123667477phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2QuickGO ontologyBLASTP
2372424272549hypothetical proteinBLASTP
2426924979711hypothetical proteinBLASTP
2500025302303PTS system LactoseCellobiose specific IIB subunitQuickGO ontologyBLASTP
2529225675384hypothetical proteinBLASTP
25946274571512HTH domain proteinQuickGO ontologyBLASTP
2766827838171hypothetical proteinBLASTP
2876528980216hypothetical proteinBLASTP
2940829611204hypothetical proteinBLASTP
2980629958153hypothetical proteinBLASTP
2998230125144hypothetical protein
3016830389222hypothetical protein
3049630651156hypothetical protein
3074331501759transcriptional regulator DeoR familyQuickGO ontologyBLASTP
3211832855738hypothetical proteinBLASTP
33522345801059histidinol-phosphate transaminaseQuickGO ontologyBLASTP
34584356151032phospholipase patatin familyQuickGO ontologyBLASTP
3560736080474acetyltransferase GNAT familyQuickGO ontologyBLASTP
3609436753660hypothetical proteinBLASTP
3700637644639SAF domain proteinQuickGO ontologyBLASTP
3764138462822hypothetical proteinBLASTP
38459399371479type IIIV secretion system proteinQuickGO ontologyBLASTP
3993440809876type II secretion system F domain proteinQuickGO ontologyBLASTP
4080241704903type II secretion system F domain proteinQuickGO ontologyBLASTP