Pre_GI Gene

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Host: NC_014039 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014039:151631 Propionibacterium acnes SK137 chromosome, complete genome

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
151631152230600N-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
1524751538481374peptidase M16 pitrilysin familyQuickGO ontologyBLASTP
1538481551191272peptidase M16 pitrilysin familyQuickGO ontologyBLASTP
155183155302120hypothetical protein
155223155744522hypothetical proteinBLASTP
1557371580822346transglycosylaseQuickGO ontologyBLASTP
1580921596391548hypothetical proteinBLASTP
1596361608111176hypothetical proteinBLASTP
1608081621451338hypothetical protein
1621061633681263glycosyltransferase group 1 family proteinQuickGO ontologyBLASTP
1636361647631128hypothetical proteinBLASTP
1647601660821323O-antigen polymeraseQuickGO ontology
166056166832777hypothetical protein
167006167623618bacterial transferase hexapeptide repeat proteinQuickGO ontologyBLASTP
1677071688191113DegTDnrJEryC1StrS aminotransferase family proteinQuickGO ontologyBLASTP
168819169811993oxidoreductase NAD-binding domain proteinQuickGO ontologyBLASTP
1699131712951383hypothetical proteinBLASTP
1714991730761578amino acidpeptide transporter PeptideH symporterQuickGO ontologyBLASTP
1731251745041380pyridine nucleotide-disulfide oxidoreductaseQuickGO ontologyBLASTP