Pre_GI Gene

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Host: NC_014039 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014039:1238500 Propionibacterium acnes SK137 chromosome, complete genome

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
123852112406682148beta-lactamaseQuickGO ontologyBLASTP
12407671241414648hypothetical proteinBLASTP
12414241242296873transcriptional regulator RpiR familyQuickGO ontologyBLASTP
12424221243336915N-acetylmuramic acid 6-phosphate etheraseQuickGO ontologyBLASTP
124335612448731518phosphotransferase system EIICQuickGO ontologyBLASTP
12452801246248969BadFBadGBcrABcrD ATPase family proteinQuickGO ontologyBLASTP
124625112472551005Tat twin-arginine translocation pathway signal sequenceQuickGO ontologyBLASTP
124725212486821431glycosyl hydrolase family 1QuickGO ontologyBLASTP
12487101249021312PTS system LactoseCellobiose specific IIB subunitQuickGO ontologyBLASTP
124902712502951269putative PTS system cellobiose-specific IIC componentQuickGO ontologyBLASTP
12503341250657324PTS system LactoseCellobiose specific IIA subunitQuickGO ontologyBLASTP
12509411251090150hypothetical protein
125162212551943573DNA polymerase III alpha subunitQuickGO ontologyBLASTP
12551911255745555hypothetical proteinBLASTP
125575012570691320histidinol dehydrogenaseQuickGO ontologyBLASTP
125706612582321167histidinol-phosphate transaminaseQuickGO ontologyBLASTP
12582291258849621imidazoleglycerol-phosphate dehydrataseQuickGO ontologyBLASTP
12588421259459618imidazole glycerol phosphate synthase glutamine amidotransferase subunitQuickGO ontologyBLASTP
12594721260239768bifunctional HisATrpF proteinQuickGO ontologyBLASTP
12603891261183795hypothetical proteinBLASTP
12611801261770591Crossover junction endodeoxyribonuclease RuvCQuickGO ontologyBLASTP
12617671262372606Holliday junction DNA helicase RuvAQuickGO ontologyBLASTP
126242612634481023Holliday junction DNA helicase RuvBQuickGO ontologyBLASTP