Pre_GI Gene

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Host: NC_012943 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012943:830000 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
830207830704498transcriptional regulatorQuickGO ontologyBLASTP
831062831610549hypothetical proteinBLASTP
831855832661807hypothetical proteinBLASTP
832695833303609hypothetical proteinBLASTP
833534833848315transposaseQuickGO ontologyBLASTP
833990834508519PE-PGRS family proteinQuickGO ontologyBLASTP
834886835443558hypothetical proteinBLASTP
835440835946507transcriptional regulatorQuickGO ontologyBLASTP
8360598362051473-hydroxyisobutyrate dehydrogenaseQuickGO ontologyBLASTP
836154836681528hypothetical proteinBLASTP
8367018390522352PE-PGRS family proteinQuickGO ontologyBLASTP
8394518420542604hypothetical proteinBLASTP
842145842402258antitoxinQuickGO ontologyBLASTP
842426842854429toxinQuickGO ontologyBLASTP
843207843476270hypothetical proteinBLASTP
8435458444298853-hydroxyisobutyrate dehydrogenaseQuickGO ontologyBLASTP
8444408456121173acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
8456198471511533methylmalonate-semialdehyde dehydrogenase mmsAQuickGO ontologyBLASTP
8473578491111755PE-PGRS family proteinQuickGO ontologyBLASTP
8493018512411941PPE family proteinQuickGO ontologyBLASTP
851540851725186transposaseQuickGO ontologyBLASTP
851939852664726hypothetical proteinBLASTP