Pre_GI Gene

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Host: NC_012943 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012943:3777371 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
377737137806673297error-prone DNA polymeraseQuickGO ontologyBLASTP
378080237821421341hypothetical proteinBLASTP
378218437833591176trehalose 6-phosphate phosphatase otsB2QuickGO ontologyBLASTP
37835963784237642enoyl-CoA hydratase echA18QuickGO ontologyBLASTP
37842383784486249enoyl-CoA hydratase echA18_1QuickGO ontologyBLASTP
378449137859181428amidaseQuickGO ontologyBLASTP
37860263786679654hypothetical proteinBLASTP
378671837882231506cyclaseQuickGO ontologyBLASTP
37882283789118891hypothetical proteinBLASTP
3789127379073716111-deoxy-D-xylulose-5-phosphate synthaseQuickGO ontologyBLASTP
379068237909632821-deoxy-D-xylulose-5-phosphate synthaseQuickGO ontologyBLASTP
37909603791955996lytB-related protein lytB1QuickGO ontologyBLASTP
379194937930011053polyprenyl synthetaseQuickGO ontologyBLASTP
37937553794147393toxinQuickGO ontologyBLASTP
37941473794455309antitoxinQuickGO ontologyBLASTP
37945293795308780transposaseQuickGO ontologyBLASTP
37952353795975741transposaseQuickGO ontologyBLASTP
379616537983602196PE-PGRS family proteinQuickGO ontologyBLASTP
37984313799303873dehydrogenaseQuickGO ontologyBLASTP
37993773800087711hypothetical proteinBLASTP
380013338020851953short chain dehydrogenaseQuickGO ontologyBLASTP
38020863802949864cyclopropane-fatty-acyl-phospholipid synthase 1 cmaA1QuickGO ontologyBLASTP