Pre_GI Gene

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Host: NC_012943 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012943:3299744 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
32997443300397654ribosomal-protein-alanine acetyltransferase rimJQuickGO ontologyBLASTP
330041833016981281molybdopterin biosynthesis protein moeA1QuickGO ontologyBLASTP
33017753302695921UTP-glucose-1-phosphate uridylyltransferaseQuickGO ontologyBLASTP
33027183303389672hypothetical proteinBLASTP
33034423303795354hypothetical proteinBLASTP
33038683304524657hypothetical proteinBLASTP
33045853305562978polyprenyl synthetaseQuickGO ontologyBLASTP
330569133068511161hypothetical proteinBLASTP
330685833094252568hypothetical proteinBLASTP
33094183310164747adhesion component transport ATP-binding protein ABC transporterQuickGO ontologyBLASTP
33104873310942456large-conductance mechanosensitive channelQuickGO ontologyBLASTP
33109623311507546pterin-4-alpha-carbinolamine dehydrataseQuickGO ontologyBLASTP
331150733129011395serine protease pepDQuickGO ontologyBLASTP
331294533144591515two component system sensor kinase mprBQuickGO ontologyBLASTP
33144593315151693persistence regulator MprAQuickGO ontologyBLASTP
331551633168891374PE-PGRS family proteinQuickGO ontologyBLASTP
3316908331708117450S ribosomal protein L32QuickGO ontologyBLASTP
331761133186181008PE-PGRS family proteinQuickGO ontologyBLASTP
331883533216362802PE-PGRS family proteinQuickGO ontologyBLASTP