Pre_GI Gene

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Host: NC_012943 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012943:2707677 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27076772708408732hypothetical proteinBLASTP
27084052709373969nucleotide-sugar epimerase epiAQuickGO ontologyBLASTP
270937027104161047GDP-D-mannose dehydratase gmdAQuickGO ontologyBLASTP
27104502710869420hypothetical proteinBLASTP
271087327121711299hypothetical proteinBLASTP
27123732713254882hypothetical proteinBLASTP
27132382713600363hypothetical proteinBLASTP
271357227153711800hypothetical proteinBLASTP
27156072716110504hypothetical proteinBLASTP
27160442716739696hypothetical proteinBLASTP
27170232717523501hypothetical proteinBLASTP
27175202718185666hypothetical proteinBLASTP
27183222718921600hypothetical proteinBLASTP
27189282719470543hypothetical proteinBLASTP
27196432720542900hypothetical proteinBLASTP
27207552721576822hypothetical proteinBLASTP
272158827226161029glycosyltransferaseQuickGO ontologyBLASTP
27226612723059399hypothetical proteinBLASTP
27231202723332213hypothetical proteinBLASTP
27235462724163618methyltransferaseQuickGO ontologyBLASTP
272423627255251290esterase lipLQuickGO ontologyBLASTP
272557827265821005arginineornithine transport system ATPaseQuickGO ontologyBLASTP
27265792726896318toxinQuickGO ontologyBLASTP
27268932727195303antitoxinQuickGO ontologyBLASTP
272720927294612253methylmalonyl-CoA mutaseQuickGO ontologyBLASTP
272946227313331872methylmalonyl-CoA mutase small subunit mutAQuickGO ontologyBLASTP
27315002732258759hypothetical proteinBLASTP
27324762732739264hypothetical protein
273283727341441308hypothetical proteinBLASTP
27342942734524231hypothetical proteinBLASTP
27345582734914357hypothetical protein