Pre_GI Gene

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Host: NC_012943 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012943:1769445 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17694451770242798DNA repair protein RecOQuickGO ontologyBLASTP
17702351771125891UDP pyrophosphate synthaseQuickGO ontologyBLASTP
17711251771553429hypothetical proteinBLASTP
17716611772053393ferric uptake regulation protein furBQuickGO ontologyBLASTP
17720501772457408transcriptional regulator arsR-familyQuickGO ontologyBLASTP
177263917740301392glycyl-tRNA synthetaseQuickGO ontologyBLASTP
177416817760151848PPE family proteinQuickGO ontologyBLASTP
177675317786211869PPE family proteinQuickGO ontologyBLASTP
177905117802261176PPE family proteinQuickGO ontologyBLASTP
17803151780614300hypothetical proteinBLASTP
17806291780913285hypothetical proteinBLASTP
17811681781494327transposaseQuickGO ontologyBLASTP
17815451782429885transposaseQuickGO ontologyBLASTP
178249317836681176PPE family proteinQuickGO ontologyBLASTP
17837991784026228hypothetical proteinBLASTP
178449217860541563membrane-associated phospholipase C 1 plcAQuickGO ontologyBLASTP
178624517878101566membrane-associated phospholipase C 2 plcBQuickGO ontologyBLASTP
178786917894191551phospholipase C 3 plcCQuickGO ontologyBLASTP
17896351789937303hypothetical proteinBLASTP
17900721790368297esat-6 like protein esxPQuickGO ontologyBLASTP
17904191790703285esat-6 like protein esxOQuickGO ontologyBLASTP
179078817927701983hypothetical proteinBLASTP