Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:678289 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6782896796381350glycerol-3-phosphate transporterQuickGO ontologyBLASTP
679911680369459transcriptional regulator MarR familyQuickGO ontologyBLASTP
682127683098972ribose operon repressorQuickGO ontologyBLASTP
683112684008897ribokinaseQuickGO ontologyBLASTP
684005684400396D-ribose pyranaseQuickGO ontologyBLASTP
6844136859031491ribose ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
685906686841936ribose ABC transporter permease proteinQuickGO ontologyBLASTP
686856687782927ribose ABC transporter ribose-binding proteinQuickGO ontologyBLASTP
687817688464648putative translaldolaseQuickGO ontologyBLASTP
6887816911802400immune inhibitor A metalloproteaseQuickGO ontologyBLASTP
691499691840342hypothetical proteinBLASTP
6918786930501173putative multidrug resistance proteinQuickGO ontologyBLASTP
6932766943281053oxidoreductase zinc-binding dehydrogenase familyQuickGO ontologyBLASTP
694447694791345hypothetical proteinBLASTP
695045695896852phospholipase CQuickGO ontologyBLASTP
6959706969711002sphingomyelin phosphodiesterase CQuickGO ontologyBLASTP