Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:5200831 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
52008315201625795metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
52016095202451843yycI proteinQuickGO ontologyBLASTP
520243252037541323YycH proteinQuickGO ontologyBLASTP
520374552055861842sensory box histidine kinase YycGQuickGO ontologyBLASTP
52055905206297708DNA-binding response regulator YycFQuickGO ontologyBLASTP
5206814520689178tRNA-AspQuickGO ontologyBLASTP
5206907520698377tRNA-GluQuickGO ontologyBLASTP
520721152085001290adenylosuccinate synthetaseQuickGO ontologyBLASTP
520871652100771362replicative DNA helicaseQuickGO ontologyBLASTP
5210105521055144750S ribosomal protein L9QuickGO ontologyBLASTP
521054852125211974DHH subfamily 1 proteinQuickGO ontologyBLASTP
52126005213538939hypothetical proteinBLASTP
5213616521384923430S ribosomal protein S18QuickGO ontologyBLASTP
52138955214416522single-stranded DNA-binding proteinQuickGO ontologyBLASTP
5214443521473329130S ribosomal protein S6QuickGO ontologyBLASTP
521492552160251101GTP-dependent nucleic acid-binding protein EngDQuickGO ontologyBLASTP
52161415216338198hypothetical proteinBLASTP
52163595217240882mechanosensitive ion channel family proteinQuickGO ontologyBLASTP
52175005218096597putative sporulation protein YyaCQuickGO ontologyBLASTP
52181175218968852stage 0 sporulation protein JQuickGO ontologyBLASTP
52189615219722762sporulation initiation inhibitor protein SojQuickGO ontologyBLASTP
52199135220785873putative stage 0 sporulation protein JQuickGO ontologyBLASTP
5220890522160972016S rRNA methyltransferase GidBQuickGO ontologyBLASTP
522163152235201890tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidAQuickGO ontologyBLASTP