Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:4877410 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
48774104878366957thioredoxin-disulfide reductaseQuickGO ontologyBLASTP
487845148799621512TPR domain proteinQuickGO ontologyBLASTP
48801024880614513transferase hexapeptide domain proteinQuickGO ontologyBLASTP
48806384881288651pyrophosphatase PpaXQuickGO ontologyBLASTP
48813564882168813prolipoprotein diacylglyceryl transferaseQuickGO ontologyBLASTP
48821934883122930HPr kinasephosphorylaseQuickGO ontologyBLASTP
48832794883659381hypothetical proteinBLASTP
48837744884223450hypothetical proteinBLASTP
488428348871592877excinuclease ABC subunit AQuickGO ontologyBLASTP
488716548891411977excinuclease ABC subunit BQuickGO ontologyBLASTP
488930248904591158transposase IS605 familyQuickGO ontologyBLASTP
48908774891260384putative lipoproteinQuickGO ontologyBLASTP
48913544891974621hypothetical proteinBLASTP
48919714892732762transcriptional regulator MerR familyQuickGO ontologyBLASTP
48930764893468393hypothetical proteinBLASTP
48934654893686222hypothetical proteinBLASTP
48936994893896198DNA-binding proteinQuickGO ontologyBLASTP
489423148952531023hypothetical proteinBLASTP
48954044896297894LysR family transcriptional regulatorQuickGO ontologyBLASTP
48963494896714366transcriptional regulator MerR familyQuickGO ontologyBLASTP
48967194897264546FMN reductase NADPH-dependentQuickGO ontologyBLASTP
489753048991641635putative macrolide efflux pumpQuickGO ontologyBLASTP
489964549013601716ABC transporter ATP-binding proteinpermeaseQuickGO ontologyBLASTP
490167249028561185hypothetical proteinBLASTP
490296649044021437carboxyl-terminal proteaseQuickGO ontologyBLASTP
49045214905414894cell division ABC transporter permease protein FtsXQuickGO ontologyBLASTP
49054044906090687cell division ABC transporter ATP-binding protein FtsEQuickGO ontologyBLASTP
49063774906700324cytochrome c-551QuickGO ontologyBLASTP
49069554907113159hypothetical proteinBLASTP
490838049108872508preprotein translocase subunit SecAQuickGO ontologyBLASTP
49111644911706543ribosomal subunit interface proteinQuickGO ontologyBLASTP
49117314911865135hypothetical proteinBLASTP
49120304912233204cold shock protein CspCQuickGO ontologyBLASTP
49123544913058705comF operon protein 3QuickGO ontologyBLASTP
491305849144071350comF operon protein 1QuickGO ontologyBLASTP
491453549158451311putative cell wall endopeptidase NlpCP60 familyQuickGO ontologyBLASTP
49160974916411315hypothetical proteinBLASTP
49165854917427843degV family proteinQuickGO ontologyBLASTP
49176674918302636hypothetical proteinBLASTP
491837749195041128transcription antiterminator LytR familyQuickGO ontologyBLASTP
491953849206531116UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP