Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:4853640 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
485235848536681311hypothetical proteinBLASTP
48536404854137498putative prophage LambdaBa03 prohead proteaseQuickGO ontologyBLASTP
485419748552371041phage major capsid protein HK97 familyQuickGO ontologyBLASTP
48553244856304981hypothetical proteinBLASTP
48563724857238867hypothetical proteinBLASTP
48573614858266906prophage LambdaBa03 site-specific recombinase phage integrase familyQuickGO ontologyBLASTP
485841048597051296phosphopyruvate hydrataseQuickGO ontologyBLASTP
485973648612651530phosphoglyceromutaseQuickGO ontologyBLASTP
48612624862017756triosephosphate isomeraseQuickGO ontologyBLASTP
486205048632341185phosphoglycerate kinaseQuickGO ontologyBLASTP
486337448643781005glyceraldehyde-3-phosphate dehydrogenase type IQuickGO ontologyBLASTP
486440548654331029gapA transcriptional regulator CggRQuickGO ontologyBLASTP
48655704865815246glutaredoxin family proteinQuickGO ontologyBLASTP
486582548671321308RNA polymerase factor sigma-54QuickGO ontologyBLASTP
48676724867878207hypothetical proteinBLASTP
48679154868457543putative lipoproteinQuickGO ontologyBLASTP
48684884868964477stage V sporulation protein ACQuickGO ontologyBLASTP
486896548699811017stage V sporulation protein ADQuickGO ontologyBLASTP
48699784870328351stage V sporulation protein AEQuickGO ontologyBLASTP
48703404870546207hypothetical proteinBLASTP
48705674871436870hypothetical proteinBLASTP
48716784872259582ATP-dependent Clp protease proteolytic subunitQuickGO ontologyBLASTP
48725834872831249phosphocarrier protein ChrQuickGO ontologyBLASTP
48728554873805951hypothetical proteinBLASTP
48738954874848954hypothetical proteinBLASTP