Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:4745053 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
47450534745583531putative lipoproteinQuickGO ontologyBLASTP
47457274746374648PAP2 family proteinQuickGO ontologyBLASTP
474643147474441014hypothetical proteinBLASTP
47474674748417951L-lactate dehydrogenaseQuickGO ontologyBLASTP
47486634748911249spore coat protein F-related proteinQuickGO ontologyBLASTP
47489254749110186hypothetical proteinBLASTP
47492574749970714CAAX amino terminal protease family proteinQuickGO ontologyBLASTP
47505584751106549putative transcriptional regulatorQuickGO ontologyBLASTP
47511104751832723metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
475197147537551785acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
47539084754024117hypothetical proteinBLASTP
475403047552021173acetyl-CoA acetyltransferaseQuickGO ontologyBLASTP
4755224475760523823-hydroxyacyl-CoA dehydrogenaseenoyl-CoA hydrataseisomerase family proteinQuickGO ontologyBLASTP
47578414757987147hypothetical proteinBLASTP
47580754758914840D-alanyl-D-alanine carboxypeptidase family proteinQuickGO ontologyBLASTP
47589374759854918proline dehydrogenase family proteinQuickGO ontologyBLASTP
47601644760409246hypothetical proteinBLASTP
47604584760760303hypothetical proteinBLASTP
476083847628472010methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
47630274763785759hypothetical proteinBLASTP
476381647657141899cell wall surface anchor family proteinQuickGO ontologyBLASTP