Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:4674235 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
46742354674618384putative comA operon proteinQuickGO ontologyBLASTP
46747144675457744hypothetical proteinBLASTP
46755084676101594bioY family proteinQuickGO ontologyBLASTP
46762494677085837hypothetical proteinBLASTP
46771914678078888UTP-glucose-1-phosphate uridylyltransferaseQuickGO ontologyBLASTP
467818746799111725phosphoglucomutasephosphomannomutase family proteinQuickGO ontologyBLASTP
46800554680660606hypothetical proteinBLASTP
468074346822271485leucyl aminopeptidaseQuickGO ontologyBLASTP
46823744683000627hypothetical proteinBLASTP
46830874683404318hypothetical proteinBLASTP
46834014683907507MutTNUDIX family proteinQuickGO ontologyBLASTP
468403146852421212pyridine nucleotide-disulfide oxidoreductaseQuickGO ontologyBLASTP
46857024686691990pyridine nucleotide-disulfide oxidoreductaseQuickGO ontologyBLASTP