Pre_GI Gene

Some Help

Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:4507966 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
45079664508397432hypothetical proteinBLASTP
45088214509048228hypothetical proteinBLASTP
45090834509265183hypothetical proteinBLASTP
45092674509503237hypothetical proteinBLASTP
45102804511065786glucose-1-dehydrogenaseQuickGO ontologyBLASTP
45110794511936858glucose uptake proteinQuickGO ontologyBLASTP
45119734512392420hypothetical proteinBLASTP
45124864512719234molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
45127224513186465molybdopterin converting factor subunit 2QuickGO ontologyBLASTP
45131834513698516molybdopterin-guanine dinucleotide biosynthesis protein BQuickGO ontologyBLASTP
451366845149571290molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
45150414515526486molybdenum cofactor biosynthesis protein MoaCQuickGO ontologyBLASTP
451556545165781014thiaminemolybdopterin biosynthesis MoeB-like proteinQuickGO ontologyBLASTP
451778445191931410collagen triple helix repeat domain proteinQuickGO ontologyBLASTP
45193674519504138hypothetical proteinBLASTP
45197114519935225hypothetical proteinBLASTP
45200134520318306rhodanese-like domain proteinQuickGO ontologyBLASTP
45205194520701183hypothetical proteinBLASTP
452075145218751125homoserine O-acetyltransferaseQuickGO ontologyBLASTP
45220614522291231hypothetical protein
45222514522715465hypothetical proteinBLASTP
452290445242711368spore germination protein GerHAQuickGO ontologyBLASTP
452428945253831095spore germination protein GerHBQuickGO ontologyBLASTP
452535945264381080spore germination protein GerHCQuickGO ontologyBLASTP
45265294526714186hypothetical proteinBLASTP