Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:4474000 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
44740004474296297minD family ATPase domain proteinQuickGO ontologyBLASTP
44743784474614237hypothetical proteinBLASTP
44746164474978363hypothetical proteinBLASTP
44750134476011999catabolite control protein AQuickGO ontologyBLASTP
447654044775561017putative lipoproteinQuickGO ontologyBLASTP
44776744478000327hypothetical proteinBLASTP
44780004478512513hypothetical proteinBLASTP
447870044798151116putative aminopeptidaseQuickGO ontologyBLASTP
44798524480286435putative lipoproteinQuickGO ontologyBLASTP
44804814480885405hypothetical proteinBLASTP
44809774481531555putative ribosomal-protein-serine acetyltransferaseQuickGO ontologyBLASTP
448172844830381311UDP-N-acetylmuramate--L-alanine ligaseQuickGO ontologyBLASTP
448329144844091119nicotinate phosphoribosyltransferaseQuickGO ontologyBLASTP
448447144884063936FtsKSpoIIIE family proteinQuickGO ontologyBLASTP
44886284488972345hypothetical proteinBLASTP
44894074490021615putative tRNA binding domain proteinQuickGO ontologyBLASTP
44900184490851834hypothetical proteinBLASTP
44909104491224315thioredoxin family proteinQuickGO ontologyBLASTP
44913084491817510NTPaseQuickGO ontologyBLASTP
449205944931321074peptidase M42 familyQuickGO ontologyBLASTP
44932814493592312hypothetical proteinBLASTP
44938284494682855metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
44947524495405654tRNA guanine-N7--methyltransferaseQuickGO ontologyBLASTP
44956384495916279hypothetical proteinBLASTP
44959204496717798aminoglycoside phosphotransferase family proteinQuickGO ontologyBLASTP