Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:4399094 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
43990944400032939malate dehydrogenaseQuickGO ontologyBLASTP
440005244013441293isocitrate dehydrogenaseQuickGO ontologyBLASTP
440150544026531149citrate synthaseQuickGO ontologyBLASTP
44030414403502462hypothetical proteinBLASTP
440392344050411119sporulation integral membrane protein YtvIQuickGO ontologyBLASTP
44056274406016390FxsAQuickGO ontologyBLASTP
440621644079731758pyruvate kinaseQuickGO ontologyBLASTP
440802744089869606-phosphofructokinaseQuickGO ontologyBLASTP
44091154410089975acetyl-CoA carboxylase carboxyltransferase subunit alphaQuickGO ontologyBLASTP
44100774410946870acetyl-CoA carboxylase subunit betaQuickGO ontologyBLASTP
44111324411776645GntR family transcriptional regulatorQuickGO ontologyBLASTP
441179144130291239putative malate dehydrogenaseQuickGO ontologyBLASTP
441313344164593327DNA polymerase III DnaEQuickGO ontologyBLASTP
44165774416915339hypothetical proteinBLASTP
44169124417415504hypothetical proteinBLASTP
44174674418399933DHH subfamily 1 proteinQuickGO ontologyBLASTP