Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:4273606 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
427360642749401335glutamyl-tRNA reductaseQuickGO ontologyBLASTP
42753564275808453transcriptional regulator MarR familyQuickGO ontologyBLASTP
42758114276227417organic hydroperoxide resistance proteinQuickGO ontologyBLASTP
42762604276856597ribosome biogenesis GTP-binding protein YsxCQuickGO ontologyBLASTP
427685342791832331endopeptidase LAQuickGO ontologyBLASTP
427936742810401674ATP-dependent protease LonBQuickGO ontologyBLASTP
428114442824031260ATP-dependent protease ATP-binding subunit ClpXQuickGO ontologyBLASTP
428266842839451278trigger factorQuickGO ontologyBLASTP
42842564285254999hypothetical proteinBLASTP
42854524285700249hypothetical proteinBLASTP
42862204286834615hypothetical proteinBLASTP
42869204287120201hypothetical proteinBLASTP
42877894288292504putative phosphoesteraseQuickGO ontologyBLASTP
42883064288914609nucleoside-triphosphataseQuickGO ontologyBLASTP
42889264289663738ribonuclease PHQuickGO ontologyBLASTP
428979242908411050germination protein gerMQuickGO ontologyBLASTP
42909724291781810glutamate racemaseQuickGO ontologyBLASTP
429199242933171326major facilitator family transporterQuickGO ontologyBLASTP