Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:4116971 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
41165044116974471putative metalloproteaseQuickGO ontologyBLASTP
411697141191152145HDIG domain proteinQuickGO ontologyBLASTP
41193094120268960PhoH family proteinQuickGO ontologyBLASTP
412027241214711200sporulation proteinQuickGO ontologyBLASTP
41216484121941294sporulation protein YqfCQuickGO ontologyBLASTP
41220504122493444gatBYqey domain proteinQuickGO ontologyBLASTP
4122509412268217430S ribosomal protein S21QuickGO ontologyBLASTP
412301341243651353RNA modification enzyme MiaB familyQuickGO ontologyBLASTP
4124372412512175016S ribosomal RNA methyltransferase RsmEQuickGO ontologyBLASTP
41252674126205939ribosomal protein L11 methyltransferaseQuickGO ontologyBLASTP
412623441273491116chaperone protein DnaJQuickGO ontologyBLASTP
412755441293891836molecular chaperone DnaKQuickGO ontologyBLASTP
41294164129982567heat shock protein GrpEQuickGO ontologyBLASTP
413009741311131017heat-inducible transcription repressorQuickGO ontologyBLASTP
413124741323831137coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
41324394132813375hypothetical proteinBLASTP
413294541347681824GTP-binding protein LepAQuickGO ontologyBLASTP
41349794135341363hypothetical proteinBLASTP
413534141364471107germination proteaseQuickGO ontologyBLASTP
4136629413688625830S ribosomal protein S20QuickGO ontologyBLASTP
413696941379791011DNA polymerase III subunit deltaQuickGO ontologyBLASTP