Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:3692803 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
369280336945121710putative fibronectin-binding proteinQuickGO ontologyBLASTP
369484036959101071putative X-Pro dipeptidaseQuickGO ontologyBLASTP
36960303696398369hypothetical proteinBLASTP
36964143696779366hypothetical proteinBLASTP
369694636983311386hypothetical proteinBLASTP
36984983698752255hypothetical proteinBLASTP
36994943700126633orotate phosphoribosyltransferaseQuickGO ontologyBLASTP
37001233700839717orotidine 5-phosphate decarboxylaseQuickGO ontologyBLASTP
37008243701753930dihydroorotate dehydrogenase 1BQuickGO ontologyBLASTP
37017503702529780dihydroorotate dehydrogenase electron transfer subunitQuickGO ontologyBLASTP
370252637057443219carbamoyl phosphate synthase large subunitQuickGO ontologyBLASTP
370572937068261098carbamoyl phosphate synthase small subunitQuickGO ontologyBLASTP
370682337081091287dihydroorotaseQuickGO ontologyBLASTP
37080933709007915aspartate carbamoyltransferase catalytic subunitQuickGO ontologyBLASTP
370915637104391284uracil permeaseQuickGO ontologyBLASTP
37105863711128543bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferaseQuickGO ontologyBLASTP
37113313712239909ribosomal large subunit pseudouridine synthase RluA familyQuickGO ontologyBLASTP