Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:3579999 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
35799993580541543spore coat protein EQuickGO ontologyBLASTP
35806673581098432hypothetical proteinBLASTP
358110235826311530dimethylallyladenosine tRNA methylthiotransferaseQuickGO ontologyBLASTP
358305935839258672-oxoglutarate ferredoxin oxidoreductase subunit betaQuickGO ontologyBLASTP
358391235856691758putative pyruvate ferredoxin oxidoreductase alpha subunitQuickGO ontologyBLASTP
35858973586820924renal dipeptidase family proteinQuickGO ontologyBLASTP
35868803587140261stage V sporulation protein SQuickGO ontologyBLASTP
35872903588084795phosphoesterase family proteinQuickGO ontologyBLASTP
358825035898121563phosphodiesteraseQuickGO ontologyBLASTP
35902953590720426recA protein group I intron-containingQuickGO ontologyBLASTP
35910273591653627protein RecAQuickGO ontologyBLASTP
359179835930361239competence damage-inducible protein AQuickGO ontologyBLASTP
35930573593635579CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
35936993594610912hypothetical proteinBLASTP
35946323595417786ACT domain proteinQuickGO ontologyBLASTP
35955573595805249hypothetical proteinBLASTP
359588135965947143-ketoacyl-ACP reductaseQuickGO ontologyBLASTP
359669835979841287zinc protease insulinase familyQuickGO ontologyBLASTP
359798535992591275hypothetical proteinBLASTP