Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:3464500 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
346877634711602385putative prophage LambdaBa01 membrane proteinQuickGO ontologyBLASTP
34726893472850162hypothetical proteinBLASTP
34728943473265372hypothetical proteinBLASTP
34732703473863594putative prophage LambdaBa01 major tail proteinQuickGO ontologyBLASTP
34738643474193330hypothetical proteinBLASTP
34741903474546357hypothetical proteinBLASTP
34745393474838300hypothetical proteinBLASTP
34748353475107273hypothetical proteinBLASTP
34751103475400291hypothetical proteinBLASTP
347543734766001164putative phage major capsid proteinQuickGO ontologyBLASTP
34766143477198585putative prophage LambdaBa01 prohead proteaseQuickGO ontologyBLASTP
347716434783751212hypothetical proteinBLASTP
347839134800611671putative prophage LambdaBa01 terminase large subunitQuickGO ontologyBLASTP
34800763480447372hypothetical proteinBLASTP
34806133480909297hypothetical proteinBLASTP
34816733482095423hypothetical proteinBLASTP