Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:3416000 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34160903416530441anti-terminator HutPQuickGO ontologyBLASTP
34167243417671948hypothetical proteinBLASTP
34176853418257573thiJpfpI family proteinQuickGO ontologyBLASTP
34182543418784531hypothetical proteinBLASTP
34190393419335297hypothetical proteinBLASTP
34194393419879441hypothetical proteinBLASTP
341990934209791071hypothetical proteinBLASTP
34215453421862318hypothetical proteinBLASTP
34220703422198129hypothetical proteinBLASTP
342247634288176342conserved repeat domain proteinQuickGO ontologyBLASTP
34288803429386507ccdC proteinQuickGO ontologyBLASTP
34294773430184708cytochrome c-type biogenesis protein CcdAQuickGO ontologyBLASTP
34303893430898510hypothetical proteinBLASTP
34311953432100906putative als operon regulatory protein AlsRQuickGO ontologyBLASTP
34322533432618366holin-like proteinQuickGO ontologyBLASTP
34326153433292678hypothetical proteinBLASTP
34333053433718414MutTNUDIX family proteinQuickGO ontologyBLASTP
34338603434060201hypothetical proteinBLASTP
34352423435388147hypothetical proteinBLASTP
343555334373371785surface-layer N-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
34374963437999504hypothetical proteinBLASTP
343806934390881020hypothetical proteinBLASTP
343920734409701764ABC transporter ATP-binding proteinpermeaseQuickGO ontologyBLASTP
344097034427211752ABC transporter ATP-binding proteinpermeaseQuickGO ontologyBLASTP