Pre_GI Gene

Some Help

Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:3320933 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
332093333227861854putative squalene-hopene cyclaseQuickGO ontologyBLASTP
33228863323311426hypothetical proteinBLASTP
33233913324332942rarD proteinQuickGO ontologyBLASTP
33244233324671249hypothetical proteinBLASTP
33248403325238399hypothetical proteinBLASTP
33252813325505225hypothetical proteinBLASTP
332552133265701050mrp proteinQuickGO ontologyBLASTP
33266373326873237molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
33268783327342465molybdopterin converting factor subunit 2QuickGO ontologyBLASTP
332732333286301308molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
332864933296651017thiaminemolybdopterin biosynthesis MoeB-like proteinQuickGO ontologyBLASTP
33296903330469780putative formate transporterQuickGO ontologyBLASTP
333065933316751017molybdenum cofactor biosynthesis protein AQuickGO ontologyBLASTP
33316963332493798formate dehydrogenase accessory proteinQuickGO ontologyBLASTP
33325103332854345hypothetical proteinBLASTP
33329703333452483hypothetical proteinBLASTP
333346433364032940molybdopterin oxidoreductase family proteinQuickGO ontologyBLASTP
33363723336563192hypothetical proteinBLASTP
333670133382391539spore germination proteinQuickGO ontologyBLASTP
333823633393331098spore germination proteinQuickGO ontologyBLASTP
333933433404701137spore germination proteinQuickGO ontologyBLASTP
33405503340684135hypothetical proteinBLASTP
334074233441043363hypothetical proteinBLASTP