Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:2175867 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21758672176202336hypothetical proteinBLASTP
21764982176710213hypothetical proteinBLASTP
217745521799172463penicillin-binding protein 1AQuickGO ontologyBLASTP
218053221816771146major facilitator family transporterQuickGO ontologyBLASTP
21816932181983291hypothetical proteinBLASTP
218238321835041122citrate synthase 3QuickGO ontologyBLASTP
2183603218503914372-methylcitrate dehydrataseQuickGO ontologyBLASTP
21850582185966909methylisocitrate lyaseQuickGO ontologyBLASTP
21859762186092117hypothetical proteinBLASTP
218612121878301710acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
21878472188737891putative 2-hydroxy-3-oxopropionate reductaseQuickGO ontologyBLASTP
218877421902341461methylmalonic acid semialdehyde dehydrogenaseQuickGO ontologyBLASTP
21903052190937633putative homoserinethreonine efflux proteinQuickGO ontologyBLASTP
2191121219217610563-hydroxyisobutyryl-CoA hydrolaseQuickGO ontologyBLASTP
21924932192750258hypothetical proteinBLASTP
21929342193173240hypothetical proteinBLASTP
219318921943461158putative exonuclease SbcDQuickGO ontologyBLASTP
219434321974323090putative exonucleaseQuickGO ontologyBLASTP
21976902197818129hypothetical protein